Izoenzym |
Substrát |
Induktor |
Inhibitor |
CYP1A2 |
bufuralol
cimeditin
clozapin
fluvoxamin
imipramin
kofein
ondansetron
paracetamol
phenacetin
tacrin
tamoxifen
theophyllin
warfarin |
cigaretový kouř
ethanol
omeprazol
phenobarbital
phenytoin
rifampicin
tělesná námaha |
ellipticin
erythromycin
estrogeny
etanol
fluvoxamin
furaphyllin
o-naftoflavon |
CYP2A6 |
warfarin |
phenobarbital |
methoxalen |
CYP2C9 |
diclofenac
ibuprofen
losartan
phenytoin
S-warfarin
tolbutamid
warfarin |
barbituraty
carbamazepin
phenobarbital
phenytoin
primidon
rifampicin |
amiodaron
fluconazol
fluoxetin
fluvoxamin
chloramphenicol
miconazol
sulphametizol
sulphaphenazol |
CYP2C19 |
amitriptylin
citalopram
clomipramin
cycloquanil
diazepam
hexobarbital
imipramin
indometacin
kyselina mefenamová
kyselina tienilová
moclobemid
nialamid
nilutamid
nirvanol
omeprazol
papaverin
phenytoin
proguanil
propranolol
R-methylphenobarbital
S-mephenytoin
teniposid
trimethadion
warfarin |
carbamazepin
phenobarbital
phenytoin
primidon |
cimetidin
felbamat
fluoxetin
fluvoxamin
ketoconazol
omeprazol
teniposid
topiramat |
CYP2D6 |
ajmalin
alprenolol
amiflamin
amitriptylin
aprindin
bufuralol
bupranolol
captopril
clomipramin
clozapin
debrisochin
desipramin
dextromethorphan
ebastin
encainid
ethylmorphin
flecainid
fluoxetin
fluphenazin
guanoxan
haloperidol
hydrocodon
imipramin
indoramin
kodein
loratadin
maprotilin
methoxyamfetamin
metiamid
metoprolol
mexiletin
mianserin
mibefradil
nortriptylin
ondansetron
paroxetin
perhexilin
perphenazin
phenformin
prajmalin
propafenon
propranolon
risperidon
spartein
thioridazin
timolol
tomoxetin
tramadol
tricyclic antidepressants
trifluoperidol
tropisetron
zuclopenthixol |
rifampicin
|
amiodaron
antipsychotics
cimetidin
flecainid
fluoxetin
fluvoxamin
haloperidol,
chinidin
levomepromazin
paroxetin
perfenazin,
propafenon
quinidin
quinidin
setralin
thioridazin
verapamil |
CYP2E1 |
chlorzoxazon
paracetamol
theophyllin |
etanol
isoniazid
cigaretový kouř
diabetes mellitus |
diethyldithiocarbamat
disulfiram
tetrahydrofuran |
CYP3A4 |
alfetanil
alprazolam
amiodaron
amitriptylin
amlodipin
astemizol
azithromycin
bepredil
bromazepam
budesonid
carbamazepin
cisaprid
clarithromycin
cyclophosphamid
cyclosporin
cyklosporin A
cyklosporin G
dapson
dexamethazon
dextromethorphan
diazepam
digitoxin
dihydroergotamin
dihydropyridin
disopyramid
ditiazem
dronabinol
ebastin
erythromycin
estradiol
ethosuximid
ethylmorphin
etoposid
felodipin
fentanyl
finasterid
fluconazol
flutamid
gestoden
chinidin
chlorozoxazon
ifosfamid
imipramin
isradipin
itraconazol
ketoconazol
kokain
kortisol
lansoprazol
lidocain
lignocain
loratadin
losartan
lovastatin
methadon
methoxymorfolinodoxorubicin
methylprednison
mianserin
mibefradil
miconazol
midazolam
mifepriston
nefazodon
nicardipin
nifedipin
nifedipin
niludipin
nimodipin
nisoldipin
nitrendipin
omeprazol
ondansetron
paclitaxel
paracetamol
pimozid
prednison
progesteron
propafenon
protease inhibitors
simvastatin
sirolimus (rapamycin)
sufentanil
sulfamethoxazol
tacrolimus
tamoxifen
terfenadin
testosteron
toremifen
triazolam
trimetadion
troleandomycin
verapamil
warfarin
zatosetron
zolpidem |
carbamazepin
dexamethason
rifampicin
phenytoin
phenobarbital
|
7-O-ethinylestradiol
azitromycin
cimetidin
clarithomycin
diltiazem
erythromycin
fluconazol
fluoxetin
fluvoxamin
gestoden
grapefruit juice
chinin
inhibitory proteáz
itraconazol
ketoconazol
lovastatin
nefazodon
norfluoxetin
setralin
troleandomycin
venlafaxin
verapamil |
